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Minority report: small-scale metagenomic analysis of the non-bacterial kitchen sponge microbiota
(2022)
Diese Bachelorarbeit beschäftigt sich mit der Erstellung eines strategischen Marketingkonzepts für das B-to-B IT-Serviceproviderunternehmen agilTech Information Technologies GmbH. Durch mangelnde strategische Ausrichtung und die vorherrschende Projektarbeit als Individualsoftware entwickler und IT-Berater, sah sich das Unternehmen bisher einem großen Absatzrisiko und einer volatilen Nachfrage ausgesetzt. So hat sich das Unternehmen opportunistisch am Markt bewegt, keine konkreten Unternehmensziele definiert und konzeptlose Marketingmaßnahmen ohne Zielgruppenbestimmung durchgeführt. Ziel dieser Arbeit ist somit die Entwicklung eines strategischen Marketingkonzepts, um agilTech wettbewerbsfähig am Markt zu positionieren, mehr Projektanfragen zu generieren und so ein strategisches Unternehmenswachstum im fragmentierten Individualsoftwaremarkt zu ermöglichen. Der Lösungsansatz dieser Arbeit basiert auf Taylor’s (2015) strategischem Marketingplanungsprozess, der sich in die Phasen Ziele und Marktanalysen, Strategieentwicklung und operatives Marketing einteilen lässt. Als Ergebnis entstand eine Marketingstrategie, Servicemarketing Mix-Maßnahmen und Kommunikationsmittel wurden identifiziert sowie Handlungsvorschläge unterbreitet. Für die Organisation und Implementierung der Servicemarketing Mix-Maßnahmen wurde ein detaillierter Plan erstellt, für die Marketing-Kontrolle je Servicemarketing Mix-Maßnahme mehrere Key Performance Indicators definiert und Messinstrumente vorgestellt. Damit das erarbeitete, strategische Marketingkonzept positive Resultate erzielen kann, ist jedoch Top Management Support in Form von Engagement sowie zeitliches und finanzielles Investment notwendig.
Die vorliegende Bachelor-Thesis beschäftigt sich mit der Täuschung auf maschinellem Lernen basierender Schadsoftwareerkennung unter realitätsnahen Bedingungen.
Neben der detaillierten Betrachtung des Forschungsgegenstandes werden hierfür, die vom aktuellen Forschungsstand hervorgebrachten Angriffe, hinsichtlich des Effektivitätskriteriums der Über- tragbarkeit auf zum Angriffszeitpunkt unbekannte Modelle, evaluiert und ein speziell für diese Bedingungen konzipierter, iterativer Ensemble-Ansatz zur Generierung von übertragbaren Adversarial Examples vorgestellt.
Die aus den Untersuchungen stammenden Ergebnissen zeigen, dass die Leistung herkömmlicher Verfahren, unter wirklichkeitsnahen Bedingungen oder im Einsatz gegen kommerzielle Produkte, stark abnimmt. Weitere Erkenntnisse der Forschung umfassen den Ausschluss eines linearen Zusammenhanges zwischen verfügbarem Wissen und Evasionserfolg, die Steigerung der Übertragbarkeit durch Zunahme der Ensemblegröße sowie die Einsatzfähigkeit der entwickelten Methodik gegen kommerzielle Antivirus Produkte.
Die Inhalte der vorliegenden Thesis verfolgen dabei einen rein edukatorischen Ansatz, der durch das Aufdecken von sicherheitsrelevanten Schwachstellen als Handlungsimpuls für Betreiber kommerzieller Antivirus-Lösungen dienen und nicht zum Begehen von Straftaten animieren soll.
University-Industry Collaboration (UIC) is considered by academics and industry as a vital factor that has the power to both positively and negatively impact the open innovation (OI). To contribute to the literature and to identify challenges as well as to conceptualize some recommendations to help industries, this thesis raised a question:
what are the challenges of UIC and what recommendations can be made to solve the challenges. The main research objective was to recognize the determinants of UIC challenges. An empirical study was conducted in order to give an answer to the research questions and to meet the research objective. This research explicitly focused on students/interns and internships to analyze and to discover the challenges and solutions since students or internships are the least researched area in the field of UIC research. Participants were personally contacted with the survey link that was created online to conduct explorative research with the help of close-ended (quantitative) and open-ended (qualitative) questions. The results reveal that there are numerous challenges students face during the internship and thus these most likely hinder the successful UIC and ultimately successful OI. According to the results obtained from both quantitative and qualitative sections obvious and major challenges lie in innovation mediators ‘organizational culture’. From the quantitative result perspective only, major challenges are in the area of absorptive capacity and supervisors' support, internalization, and trust. Similarly, from the qualitative results perspective only, major challenges are bad crisis management, communication, and hierarchical structure.
Germany has a long history in the car sector. However, today’s car industry is drastically changing, triggered by the accelerated rise of new technologies, sustainability policies and changing consumer preferences. The purpose of this research project is to forecast, by using the scenario planning software INKA 4, the future of cars in Germany in 2035. The research project focused mainly on cars based on internal combustion engines (ICE), fuel cell vehicles (FCV), battery electric vehicles (BEV) and Hybrid electric vehicles (HEV) and their charging infrastructure in Germany. Also, the future of autonomous driving vehicles, public transportation and carsharing in Germany were taken into consideration. Considering these factors following four areas of influence were chosen: Technology, Economics, Politics and Social. Within these areas of influence thirteen input factors (descriptors) were defined by research on current literature. The results show three distinct scenarios that reflect a possible shift towards electric mobility, autonomous driving, and an increase in the use of car sharing.
Key findings
The future of cars in Germany is affected by four areas of influence: Technology, Economics, Politics and Social. Among those four areas, a total of thirteen descriptors were selected as an input for the scenario building.
With the software INKA 4 five different scenarios were generated. Three distinctive scenarios were chosen and described to outline the future of cars in Germany in 2035.
It is highly probable that the future cars will be electrified and autonomous and that shared mobility will increase. The extent of the aforementioned change until 2035 depends highly on the German government and customer preferences.
Individual medicine gained increasing popularity in the medical industry in the past years. Especially oncology plays a major role in individual medicine, as significant research has been done in this area in the last decade. In order to provide individual treatment to patients, individualized medicine in cancer therapy uses molecular genetic examination of blood or tumor tissue.
This paper discusses individual treatment approaches for the selected diseases of prostate cancer and leukemia. Individual medicine in prostate cancer is still considered to be in its infancy whereas in leukemia it is already advanced. Conventional treatment in prostate cancer is highly standardized and well-developed and thus, individual approaches in PCa are not yet well-established or well-researched. Therefore, the relevance of individual treatments in prostate cancer is still to be discussed. In contrast to that leukemia has a promising future in the area of individualized medicine. However, individualized treatments are still very expensive and health insurances only cover a limited amount of financial expenses. As genetic testing is becoming more significant and is likely to be used more often in the future, the cost for individual treatments are expected to decrease over time. Also, this paper suggests future implications for the application of individual medicine in Germany in the areas of health care promotion, disease prevention and disease management until the year 2030.
Highlights of the paper:
• Individual medicine in leukemia is already well-established, however necessity of individual approaches in prostate cancer is discussed
• Individual medicine is currently very cost-intensive but increases the quality of life and the lifespan.
• In order to implement individual medicine in the future it is anticipated to improve health care promotion, disease prevention and disease management.
A special generative manufacturing (AM) process was developed for the partial integration of active ingredients into open-porous matrix structures. A mixture of a silver-containing solution as an antibacterial material with an alginate hydrogel as a carrier system was produced as the active ingredient. The AM process developed was used to introduce the active ingredient solution into an open-porous niobium containing a β-titanium matrix structure, thus creating a reproducible active ingredient delivery system. The matrix structure had already been produced in a separate AM process by means of selective laser melting (SLM). The main advantage of this process is the ability to control porosity with high precision. To determine optimal surface conditions for the integration of active ingredients into the matrix structure, different surface conditions of the titanium substrate were tested for their impact on wetting behaviour of a silver-containing hydrogel solution. The solution-substrate contact angle was measured and evaluated to determine the most favourable surface condition. To develop the generative manufacturing process, an FDM printer underwent modifications that permitted partial application of the drug solution to the structure in accordance with the bioprinting principle. The modified process enabled flexible control and programming of both the position and volume of the applied drug. Furthermore, the process was able to fill up to 95% of the titanium matrix body pore volume used. The customised application of drug carriers onto implants as a drug delivery system can be achieved via the developed process, providing an alternative to established methods like dip coating that lack this capability.
Prior research on choice in context demonstrated extremeness aversion to be very effective on consumers’ purchasing behaviour. However, it seems that previous studies have neglected to investigate the impact of the spatial arrangements of choice architectures on consumers purchasing behaviour. Based on indications of prior research, we pursued to demonstrate in this study that consumers who are uncertain regarding their
preferences tend to search for alternatives in the middle of a choice architecture. Therefore, we hypothesized that an alternative, positioned in the middle of a choice architecture, will present a relatively higher choice share. To research this hypothesis we conducted an online survey mainly in Central Europe, which involved a total number of
901 respondents at the age between 15 and 95. The study’s results demonstrate that the decision making of the majority of the participants is heavily influenced by a choice architecture’s spatial arrangement. It became evident that the choice share of one
alternative was higher when presented in the middle of a choice architecture than when presented in the periphery.
Akademisch qualifizierte Pflegefachkräfte sind prädestiniert dafür, erweiterte Rollen, Aufgaben und Spezialisierungen im Versorgungsgeschehen zu übernehmen. Ziel einer solchen Neuausrichtung in der Pflege ist es, Patienten*innen, Bewohner*innen in Pflegeeinrichtungen und Bürger*innen eine medizinisch-pflegerische Versorgung auf qualitativ hohem Niveau zukommen zu lassen. Dazu gehört auch die Sicherung und Verbesserung der Versorgungsqualität. Die erweiterte und fortgeschrittene Pflegepraxis durch akademisch qualifizierte Pflegefachkräfte in spezifischen Versorgungsbereichen bewährt sich seit vielen Jahren z.B. in den angelsächsischen oder skandinavischen Ländern und wird auch in Deutschland bereits an bestimmten Standorten umgesetzt. Dennoch sind zukünftige Handlungsfelder, Aufgaben- und Verantwortungsbereiche von akademisch ausgebildeten Pflegefachkräften unzureichend erprobt und strukturell beschrieben.
Kriterien zukünftiger Aufgaben- und Verantwortungsbereiche akademisch ausgebildeter Pflegefachpersonen in der ambulanten, stationären Langzeitpflege und im Quartier sowie die Ableitung vertraglicher, leistungs- und ordnungsrechtlicher Rahmenbedingungen und Empfehlungen für deren Einsatz sind herausgearbeitet wurden. Konkrete Handlungsempfehlungen für den Einsatz von akademisch ausgebildeten Pflegefachkräften und für die dazu erforderlichen Rahmenbedingungen sind beschrieben und formuliert worden, um so das Verständnis einer erweiterten Pflegepraxis zu fördern.
Due to continuous changes in consumer needs, new product development (NPD) and innovation are some of a company’s key factors of success and competitiveness. In order to be successful, companies have to understand consumer needs and ‘translate them into new products’1. If changing consumer perceptions and their requirements are not respected by a firm, a product’s sales will decrease as people no longer feel satisfied with the old product and require new functions. Therefore, a major task in business is being close to the customer. In order to collect ideas about product perceptions, institutions and departments within a company staying in direct contact with consumers can be essential. One department that represents a customer-oriented sector is sales, as their day-to-day business includes communication with customers.
However, failure rates of new product launches are still very high. According to a study of Serviceplan and Gfk where 265 newly launched products were analyzed, 70% of these failed and were no longer bought after only one year.2 A firm’s difficulties in generating ideas in the early stages of NPD have been ‘identified as major cause of notoriously high failure rates of new products’3. One possible reason is that information received by the sales department is not communicated clearly enough to Research & Development (R&D), which is in charge of developing new products. For this reason consumer needs are often not adequately integrated into the process of new product development and relevant information concerning their requirements can get lost.
The question as to how the customer-oriented sales department can be better involved into the process of new product development in order to ensure the success of new product introductions will be discussed in the following.
Diese Arbeit behandelt mehrere Konzepte zur Leistungsbewertung von eingebetteten und Echtzeitsystemen. Das Ermitteln von oberen Zeitschranken, insbesondere der schlechtesten Ausführungszeit, lässt sich durch Verwendung von Zeitanalysen realisieren, wobei zwischen statischen und messbasierten Zeitanalysemethoden unterschieden wird. Für die Gesamtbewertung des Systems ist Benchmarking eine geeignete Methode, um wichtige Zeitparameter zu messen und diese ggf. in den Vergleich mit anderen Systemen zu setzen. Der Einsatz von Simulationen zur eistungsbewertung erweist sich als besonders sinnvoll, wenn die Kosten eines Fehlers unakzeptabel hoch sind oder die Validierung mit der Realkomponente unpraktikabel ist und somit Qualitätsmaßnahmen durch fr¨uhzeitige Validierung
benötigt werden.
Assessing the impact of a structural prior mask on EIT images with different thorax excursion models
(2023)
Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis
(2016)
Age-related changes in trunk muscle activity and spinal and lower limb kinematics during gait
(2018)
Introduction: Since the first revolution of robotic-assisted surgery officially happened in 2000, the healthcare service worldwide has transformed into a new era due to its superior technological advancements, particularly in laparoscopic surgery. Da Vinci which is seen as a master-slave system and Kymerax which is categorized as a hand-held device are commonly used in robotic-assisted laparoscopic surgery. Whilst a conventional or open method requires a large incision to perform a surgery, laparoscopy - a minimally invasive surgery (MIS) is an advantageous surgical method which reduces an abdominal incision to a minimum, and effectively exploited with robots.
Methods: Based on available articles with the object of robotic surgical surgery, two SWOT analysis for Da Vinci and Kymerax were formulated to understand strengths, weaknesses, opportunities and threats of each system in comparison with the traditional laparoscopic surgery. From that, the future outlook is anticipated based on the scientific background.
Results: Alongside technological advantages of Da Vinci mainly known as 6-degree of freedom, dexterity enhancement, stereovision, tremor filtering and especially minimal invasive surgery, it still has disadvantages that are not neglectable such as huge investment and lack of haptic feedback. Although the malfunction rate of Da Vinci is not significantly high, surgeons should be aware of it to fix or alter instruments in time. Kymerax is not as advanced as Da Vinci but it can fill in the gap of the Da Vinci which includes thelarge investment and bulky instruments. The Kymerax is the low-cost hand-held device allowing multiple degrees of freedom. It is an optimal combination between traditional performance and robotic performance allowing surgeons to manipulate in their hands and ensure haptic feedback.
Conclusions: Both Da Vinci and Kymerax systems offer superior benefits for medical service due to the ongoing technological growth. The cost-effectiveness of Da Vinci system is currently a problematic issue when medical institutions consider to install them. The surgical instruments market, however, has become highly competitive which is likely leading to the decline of the costly investments. In the digital world nowadays, it will be a promising future for more integrated medical inventions.
Trends and Advances in the Characterization of Gas Sensing Materials Based on Semiconducting Oxides
(2018)
Hydroxyethylamide substituted triterpenoic acids hold good cytotoxicity for human tumor cells
(2022)
Assessment of Neck Muscle Shear Modulus Normalization in Women with and without Chronic Neck Pain
(2022)
Die vorliegende Bachelorarbeit gibt einen Überblick darüber, inwiefern die gängigen Nachhaltigkeitslabels in Deutschland eine Hilfe für den nachhaltigen Konsumenten sind.
Dazu wurden 8 handelsübliche Labels miteinander verglichen. Das Hauptproblem der Labels war die fehlende Glaubwürdigkeit, aufgrund von fehlender Transparenz. In einem zweiten Schritt wurde ermittelt ob, und wenn ja, um wieviel sich die persönliche Zahlungsbereitschaft auch tatsächlich erhöht. Festgestellt wurde, durch Auswertung diverse Studien, dass sich die persönliche Zahlungsbereitschaft durchaus steigern lässt. Dazu muss die Preisbildung allerdings transparent nachvollziehbar sein. Es lässt sich sagen, dass sich die Zahlungsbereitschaft um ein Fünftel steigern lässt. Durch die Auswertung diverser Studien wurden Barrieren ermittelt, welche einen nachhaltigen Konsum erschweren. Auf Grundlage dieser Barrieren, wurden Handlungsempfehlungen entwickelt, durch die diese Barrieren überwindet werden könnten. Besonders interessant ist diese Arbeit für diejenigen, die den nachhaltigen Konsum fördern möchten. Dazu gehören die Initiatoren der bisherigen Labels, sowohl als auch zukünftige Initiatoren.