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Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding
(2011)
Testing applications for SmartHome environments is quite complicated, since a real environment is not accessible or the conditions are not controllable during development time. The need to set up the whole hardware environment, increase the complexity of these systems enormously. Therefore, it is helpful to simulate the SmartHome hardware components and environment conditions (e.g. rain, heat, etc.). This paper contains an approach to improve the test and demonstration process of Internet of Things scenarios. A prototype (ScnSim: Scenario Simulator) was developed to set up scenarios. The user of the ScnSim can create her/his own scenario using items (sensors/actuators) and rules, which control the sensors and actors building the IoT enviornment. This simulator is supposed to support the user testing IoT applications or configurations of SmartHome platforms like openHAB. In addition, the ScnSim is supposed to help demonstrating showcases, for example, often demonstrated on a trade fair or as a proof of concept for a customer.
Compared to relational databases, graph database systems provide a novel way of processing and analyzing highly interconnected data. Due to their unique properties, graph databases embody an interesting area of research in academic circles. For this reason, this work is fundamentally concerned with examining the state of the industry and current challenges. In this regard, we revisit the basic concepts and highlight the tremendous heterogeneity of available systems using the example of differing path semantics. Based on this insight, we explore algorithmic advancements for graph query processing regarding path finding and worst-case optimal joins. Subsequently, we discuss issues regarding performance and support for graph analytics. Finally, we provide an overview of GQL, a joint standardization effort towards unification of property graph databases.
Wikipedia is the largest free encyclopedia and one of the most popular websites worldwide. Analyzing user activity within this encyclopedic ecosystem represents unique opportunities for academic research and analysis. For this reason, this work is fundamentally concerned with obtaining and processing real-time article edit streams from Wikipedia. In this regard, we leverage the Wikimedia EventStreams API and propose a general-purpose event pipeline allowing for further processing of observed page edits. In the suggested pipeline, events are ingested and transported via an Apache Kafka cluster and inserted into a ClickHouse database for storage and analysis. Finally, we confirm the viability of our design by exploring several exemplary analytical use cases.
Optogenetics and optogenetic systems cover a wide range of applications in the research of neurological pathways. In this overview, relevant aspects regarding the development of optogenetic systems should be shown. These are the optogenetic systems – opsins and optical switches – as well as optoprobes, materials, application areas and limitations of these applications. Additionally, a short outlook should be given. No detailed analysis for specific optogenetic systems or their partial aspects were carried out.