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Clinical Research is expanding into an international and more regulated environment, specifically its quality management. Pharmaceuticals and Research Organizations are investing significant amounts of money as well as the regulatory agencies. The U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) are improving and developing regulations and meetings to standardize globally these practices. Therefore this Thesis integrates and extends the FDA and EMA recommendation of implementing “Risk based quality management” in Clinical Research protocol execution with a multisource point of view and the proposal of adding a Risk Management Report as an output, which will work also as an input for future protocols implementation. Diverse articles and regulations related with Quality Management and Clinical Research Processes were reviewed to work as a base for the analysis of this thesis. Risk Based Quality Management is the actual trend and newly implemented process to improve quality in clinical research. The goal of this Thesis is to combine the different actual factors, methods and regulations in order to expand Risk Based Quality Management and reach a better degree in quality and standardization. The question therefore is whether this redesigned Risk Based Quality Management process can really be incorporated with the actual practices, and if it is possible to adopt it in Clinical Research.
Globally operating stamping and hybrid parts manufacturer KRAMSKI and the FRANUHOFER IPA have developed a new prosthetic foot designed for developing countries. Although low-cost solutions in developing countries exist, these significantly lack functionality. The new prosthetic foot will be more expensive than most low-cost alternatives, which start from $ 5.00 for a simple SACH foot, but can be sold for a much lower price than most high-tech prosthetics imported from industrialized nations, which can cost more than $5,000. The purpose of the paper was to determine the market potential for the prosthetic foot, to monitor the competition and to create an overall marketing concept for distributing and promoting the product. Therefore market and competitor analyses were conducted. On base of the market and competitor research, strategies were formulated. As a last step, the marketing mix with its four elements was regarded and different distribution and promotional tools have been reviewed to propose marketing activities that could be undertaken by KRAMSKI. Since six different target countries in Asia and Latin America (India, Sri Lanka, Cambodia, El Salvador, Guatemala, and Honduras) were chosen in agreement with KRAMSKI, the market potential for each of these countries was estimated. Two different approaches were used to estimate the market potential of each country. Following the first approach, the total market demand of all six countries added up to more than 5.6 million potential. The second approach added up to a total of 6.7 million potential customers for the target regions. The numbers revealed that 95 % of all lower limb amputees lived in India. Therefore India has been chosen as the target country for all further research in the paper. The monitoring of the market change revealed that prosthetic foot demand was going to increase over the next decades due to lost limbs through road traffic incidents and diabetes. Besides, by the year 2030 most of the world’s middle class (80 %) will be living in developing countries As a consequence, more people will be able to afford health care products such as prosthetic feet. It has been found out that customers in developing countries lay emphasis on either low cost or quality. As a second step, the competitive environment within the prosthetic foot sector in India has been analyzed. Although the Indian healthcare system is still underdeveloped, the sector offers future opportunities for the private sector. The biggest commercial manufacturers of prosthetic feet in India are Otto Bock, Endolite and Streifeneder-Collegepark. But also international and local NGOs, such as BMVSS (Bhagwan Mahaveer Viklang Sahayata Samiti) with the Jaipur Foot, distribute prosthetic feet. Most of the commercial products are significantly more expensive than the products distributed by NGOs. Most NGOs manufacture prosthesis by themselves in order to save costs and create jobs. Many amputees can receive the prostheses and service for free due to donations which finance the NGOs. The competitive suppliers either own fitting centers or distribute their products through local wholesalers. On base of the market, consumer segmentation has been conducted. The Indian population has been divided into different income levels. Rural aspirers and urban seekers could be seen as the most profitable target segments, but urban customers might be easiest to reach due to location. In a last step, the marketing mix for the prosthetic foot has been analyzed. The prosthetic foot should offer specific features to align with developing countries. The product needs to be priced according to company objectives, demand, cost and competition. Since KRAMSKI does not yet have the capabilities and resources to fit prosthetic feet, the company needs to distribute to the end-user through indirect distribution channels such as wholesalers, clinics and NGOs. Therefore an important activity for KRAMSKI is the acquisition of distribution channels. This can be approached through promotional tools such as personal selling, direct marketing, online marketing or the participation on trade fairs and exhibitions.
Background
The recent worldwide financial crisis that occurred in last quarters of 2007 up until mid 2009 was accompanied by the massive failure of many financial institutions and liquidity providers. Investment banks and other institutionalized financial investors were unsuccessful in producing any real returns for their clients. This drastic fail in all the other traditional investments led to the questioning of how well the hedge fund industry performed in this light based on their promise as absolute return producers regardless of the market environment. This paper seeks to analyse the performance of the Long/Short Equity Strategy in particular relative to the performance of the overall market.
Methods
Thorough examination and validation of numerous empirical studies which have already been carried out on the subject matter are brought to light through the analysis of available historical data of the returns posted by these funds during the crisis using generally accepted statistical funds’ assessment tools giving an adequate angel to the performance of Long-Short Equity hedge Funds especially at the heart of the financial crisis in the last quarters of 2007 to mid 2009.
Results
Equity Long/Short Hedge funds as every other strategy in they industry succeeded in 2008 in outperforming other traditional investment vehicles and the broad stock an bond markets although the failed in to produce the absolute returns promised to their investments. In 2009 they posted similar results to that of S&P 500 index with subsequent declines in 2010 and 2011 thus failing to period their returns where highly correlated with that of the overall market coined with negative skewness and high kutorsis.
Conclusion
Even though hedge funds succeeded in outperforming the market in the heart of the crisis, they failed to provides their investors with absolute returns and also the benefits which the provide in terms of diversification to reduce the exposure of their funds to market risk was limiting. The very high fees paid to them by investors was not justified by their performance.
Optimizing the grinding process through reduction of the loading of grinding tool by infiltration
(2015)
This paper analyzes the importance of recommender systems for B2C e-Commerce businesses, using extensive literature review as well as a consumer survey. Readers will gain a basic understanding on how the technology behind the recommendation works, how competitiveness in e-Commerce can be defined and what the consumer perspective on recommender systems is. The paper will ultimately provide valuable insights into how recommender systems can create a major competitive advantage for online retailers and why an online-shop without a recommender engine will struggle to stay or become competitive.
Commissioning rules for optimal velocity controller damping of servo axes using elimination methods
(2015)
In the last 30 years academics were exploring the field of ethical consumption and identified an attitude - behavior gap in the decision making process. Since then diverse studies have been implemented to understand ethical consumers' attitudes, motives and behavior. Parallel to the academic research being developed, there had been an increasing interest from the consumer side in behaving and consuming more ethically. Particularly, consumers have inclined their ethical purchases towards fair trade products. The present exploratory research implemented a quantitative metaphoric method called Zaltman Elicitation Metaphoric Technique (ZMET) to further contribute in the literature of ethical and fair trade consumption. The ZMET in-depth interviews were carried out with 10 German fair trade food consumers during the months of February and March in 2015. The results revealed a connection between participants' feelings, emotions, personal values and fair trade food consumption; likewise the research identified an association of fair trade to sustainability.
The topic of change management gained significant importance within recent years. Through the internationalization of markets, became relevant to consider factors such as intercultural management and communication. Often managers are not able to control and coordinate these projects in an adequate manner.
One of the main reasons is the c different mindsets, expectations, ideas and working styles. During the planning and execution of change projects there is much focus on the strategy and the lead project teams. Nevertheless, employ because the foreign workforce as a whole consists of many different people from various
countries and cultures. Ensuring that a change can successfully be applied at all locations is a major task and failing in managing those varieties can lead to failure of the entire change. The regional management is often faced with inadequate decisions or poor communication by the headquarters. Additionally, even more than normal mid able to work with decisions they do not understand or support required to follow instructions from the other side of the world requires various skills. The purpose of this research is to identify the requirements of good communication a
management in regional offices in this context and to analyze how a well defined scope of responsibilities can lead an international change project to success.
Over the past years, operating conditions of German retail banks have been significantly altered by increased regulation, digitalization and new competitors. Consequently, numerous market participants have begun supplementing or replacing traditional processes with technology-based ones. Wüstenrot Bank AG Pfandbriefbank (WBP), a midsize financial corporation located in Ludwigsburg, Germany, is a primary example for this development. Notwithstanding all reforms, WBP suspects that many of its online products are unprofitable, yet has been unable to perform accurate measurements. Research shows that this is by far no exception and that in spite of digitalization’s proven impact in other industries there are very few empirical studies comparing traditional and technology-based processes in retail banking. This paper aims at filling this gap by determining the present efficiency of technology-based processes at WBP and their potential for aiding optimizations in the field. The paper uses process costing for evaluating present profitability, a methodology proven in manufacturing and other service industries yet relatively new to banking, and thus also sets a methodological recedent. For this method processes are first modeled using the ARIS concept of Scheer (1990); following Cooper and Kaplan (1988) and Horváth and Mayer (1995) costs are then determined for individual process steps based on their resource consumption and finally aggregated into the entire process. In a second step the present
situation serves as basis for simulating hypothetical scenarios used for assessing the effectiveness and impact of technology on further optimizations.
The research finds that in the case of daily money, a typical online product, neither WBP’s traditional nor its technology-based processes are profitable in the first year after account generation. In fact, losses are so extensive it is likely the product is generally unprofitable. In addition, the analysis finds that, contrary to the initial hypothesis, technology-based processes are even less efficient than traditional ones. Through subsequent simulations it becomes clear, however, that rather than digitalization all together, it is the insufficient degree of use of technology that causes costs to be so high. Therefore, optimization potential is much higher for technology-based than for traditional processes. Consequently, the paper recommends further increasing the use of digital technologies and finds process costing to be the ideal tool for capturing the best of digitalization both within WBP and in the industry.
In recent years the Green Bond market has shown a tremendous growth. It would be interesting to see where the motivation of the issuing companies comes from. One theory is that they expect to have a lower credit spread in this new market segment then in the normal bond market. It is the goal of this paper to analyse if this is the case or not. To do such an analyse it is necessary to find a connection between sustainability and classical capital market theories. Due to a lack of common understanding and measurability of sustainability this is not easy to do. Nowadays it is not possible to give a price for social benefit and as a result it is also not seen in the credit spread.
This thesis deals with the investigation of internationally operating project teams, using the automotive division of the cooperation partner and topic initiator Marquardt Group. The overall research question examines which skills in terms of emotions, culture and know how are required from program managers as a result of globalization. Background information about globalization, project management and the company itself is provided as a first step. In order to get an overview, qualitative expert interviews are conducted with program managers, their superiors, disciplinary supervisors and team members. The interview process serves to gain a stronger knowledge of the weaknesses in project management within the Marquardt Group. The results reveal clear problems, particularly in the analyzed subject areas processes, intercultural competence and communication.
Further information concentrating on intercultural competence and its potential training measures, as well as communication in so-called virtual teams due to the lacking face-to-face communication is given, followed by recommendations for improvements for the analyzed fields with weak points. It can be concluded that globalization and the consequent internationalization have a major impact on project teams requiring especially the advancement of professional, the related methodological, as well as leadership and social competences of program managers.
Der steigende Kosten- und Wettbewerbsdruck stellt Unternehmen immer wieder vor neue Herausforderungen bei der Entwicklung und Gestaltung von Produkten. Die Ausweitung der Lean-Philosophie auf die Produktentwicklung bietet ein enormes Potenzial, um in der Produktion anfallende Verschwendung bereits während der Entwicklung zu reduzieren. In dieser wissenschaftlichen Arbeit wird ein Modell entwickelt, durch welches der Wirkzusammenhang zwischen einzelnen Produktgestaltungsrichtlinien und die in der Produktion anfallende Verschwendung bewertet werden kann. Der Fokus dieser Bewertung liegt vor Allem auf den Ursachen, die zu Verschwendung führen.
Business includes interactions both in societal and organizational dimension. And interactions are done through communication. Communication is not just about sharing ideas through words. Communication is anyway a complex phenomenon. However in the age of the global business, where culture has become the core and with that more complex and therefore is neglected more than before. Besides, cultural aspects seem not to have given enough importance, in spite of doing business internationally, where culture plays an essential role. Thus global business, in form of overseas, offshoring, outsourcing, franchising, expatriates, investment etc. is a game where international entrepreneurship, intercultural challenges, culture, communication and results, leading either to successful and effective cooperation or disputes and conflicts, have a main role. Hence, this thesis, Intercultural challenges for international Entrepreneurs in Nepal and guidelines, instruments and recommendations for solving them, is all about how to combine these elements and deploy strategies by entrepreneurs from Germanic Europe while doing business in Nepal, considering the cultural differences of both cultures. Consequently the aim of this thesis is to provide with essential components concerning cultural differences that should be considered seriously while doing business in Nepal. A research conducted through questionnaire to obtain results in order to identify the most important cultural differences in terms of dimensions facilitated to develop strategies. To get to the recommendations, as the end part of this thesis, first some basic terminologies and concepts will be conceptualized. After, deeper concepts regarding the role of communication and language will be provided to reach the research part. Once, some concepts are explained in research part, results and findings will be illustrated before reaching to recommendations and conclusion. To conclude, strategies in this thesis are presented in form of recommendations and instruments according to the results, which show that there are few differences in some cultural dimensions and there are huge differences in some cultural dimensions, to foster cross-cultural cooperation without conflicts and disputes.
In recent times, China’s role in the clothing industry has been threatened. China’s ability to compete on a cost basis is diminishing and urges the country to find a new means of competition. The aim of this study is to assess China’s future role in the industry with special regards to European apparel manufactures. This is done by taking a closer look at several factors that have an impact on the industry. The analysis of published data, conducted studies and expert opinions brought to light how the government is actively involved in the pursue of maintaining China’s leading role in the textile and clothing industries as these are important contributors to China’s economic well-being. Two strategies have been emphasized. Firstly, the upgrading of the industry as a means of differentiation that allows China’s clothing industry to compete on other factors than costs. Secondly, the boost of China’s domestic market in order to mitigate against the risk arising from the volatility of markets and increased need for speed in the industry. While China’s role is undoubtedly changing, it seems like the country has found opportunities to maintain an important position in the future of the clothing industry.
Unfortunately, even in these years of high innovations in society, many countries still have gaps in basic needs such as energy supply. Many people live off-the-grid (OTG) referring to not being connected to the main or national electrical grid since they live scattered or in remote location or simple because it is unaffordable. On the other hand, according to the International Energy Agency (IEA), the use of fossil energy increased in the 8 firsts years of the 2000 decade, and half of the energy use in the last decade was accounted to coal. This type of energy source is proven to be harmful for the environment contributing to global warming. New methods of energy storage have been created mainly in developed countries. For example, the photovoltaic (PV) lamps as the main product of a German company that fulfill needs in sustainable and renewable energy resources. However, developing countries may also need to look for practical solutions and the private sector can help. The financing of renewable alternatives is imperative to increase progress and, in these sense, private sector can help. For instance, increasing systems using solar energy for rural communities and promotion of affordable and efficient PV products such as portable eco-friendly solar lamps that replace the kerosene lamps, fan plus lamps, water filters and icemakers among others are helpful in OTG communities and need to be supply. Entrepreneurs that focus in fulfill this gap in society creates value and make a change in the countries. The importance of increase electronic appliances (energy-efficient) and “smart” applications (home area networks and energy storage devices) is undeniable for progress in developing countries and better energy use all over the world Solar energy provides products that not only help people but also maintains a balance between nature and habitants.
Market entry strategy for German mittelstand medical device
companies into the Indian market.
(2015)
German medical devices companies are at the forefront of technology when it comes to innovation and R&D. Most of the European medical device manufacturing companies are located in Germany and the number of patents filed by these companies shows the amount of innovation in the industry. A majority of these medical devices are exported within the European Union countries. Economic slowdown combined with market saturation and increased competition makes Europe a very competitive market for these companies. Indian on the other hand is one of the fasted growing economies in the world. The Indian medical device sector is relatively an untapped markets for innovative medical devices. There are tremendous market opportunities due to the fact that local manufacturing base for medical devices are underdeveloped
and often neglected. Most of the local Indian manufactures are engaged in producing basic medical devices and mostly into medical disposables and supplies. Around 70% of the medical devise sold in India are imported products. There is a huge demand and supply gap that is not being filled by the local manufacturers. India offers the perfect new market opportunity for German medical companies looking to venture into emerging new markets. There is abundant supplied of skilled manpower, with wages lower than that of the neighbouring China. India also has a rapidly growing middle class with increasing purchasing power. However, the regulations in the Indian medical device industry are not very clear and transparent. The Indian bureaucratic system is rampant with corruption and red tapes that needs to be tackled and navigated skilfully. A Germany company looking to enter the Indian market needs to understand that nothing in India can be implemented by a text book style entry strategy. In this thesis, we will analyse few of the most suitable entry strategies for German medical device companies with the advantages and disadvantages of each entry mode. We will also analyse the process of doing business in India, which requires an understanding of various aspect of the Indian culture and business relationship building in India. Further, we will analyse the current market scenario with a brief analyse of the local manufacturers currently in the market along with some information on foreign players in the market. Will also interview 5 experts from the medical field and look into few real case studies.
Teaching old electronics, new tricks: medical applications of well-known industrial electronics
(2015)
In a fast-paced change and development of the work environment, organizations are faced with the need to adapt efficient and proactively on a continuous basis. Correspondingly it is important for companies to readjust their tools, requirements and processes. Performance appraisal is not an exception. Moreover it is an important part of an organization’s performance management system that assures an integer alignment of the employees’ activities and performances with the company’s strategy and goals. It is a tool, which directly addresses companies’ most important and susceptible to change resources - it’s employees and strategy. Therefore the scope of this paper was to analyze whether the traditionally used performance appraisal system of the present, would work and fit under the challenges and changes of the future of work trends. First, the paper focuses on the analysis of the future of work environment. There are initially researched the forces that will influence future organizations and then the impact on organizations is described. The above mentioned were followed by the analysis of the currently perceived drawbacks of performance appraisal as from studies and researches done by experts in the domain. The analysis points out the most important features referred to as being of a tremendous impact on the success and result of the tool. These faults of the traditional approach would be then compared with the main trends determining future of work, and as a result of the study is the determination whether the tool would perform better in the future organizational setting or worse depending on how the criteria concluded as being most influential would co-work. In conclusion it was observed that performance appraisal as such would still be an important tool in the future organization as it’s commonly perceived scope would gain in importance. However, the approach and implementation would have to be drastically reconsidered. As most of it’s currently perceived drawbacks would be in an even more devastating conflict in the upcoming time of business and employment. It refers to it’s form, owner, customer and implantation, all of these would need an radical transformation.
Purpose: This study investigates the role that entrepreneurial talents play, and the influence of such
talents in firms’ success and raising funds through crowd-funding platforms as well. It discusses and analyses which talents are needed by entrepreneurs in order to place them in the best position to attract funds from these platforms. Further, the study attempts to create a bridge between entrepreneurial talent and crowdfunding, hence acting as one of the contributors towards the entrepreneur’s business success. Design/Approach/Methodology: This topic is a novel idea and it aims at examining whether or not entrepreneurial talents, as influencing factors should be taken into account when raising funds from crowdfunding platforms. This paper includes two main parts: theoretical and practical. In the final part, this paper provides lessons learnt. Originality/Value: This thesis will add value to research in the field of crowdfunding and its operation especially when entrepreneur funding is considered. Additionally, the hypothesis that forms the basis of this thesis, advocates for a new mode of sourcing for funds from crowdfunding platforms. This new approach is premised on the idea that the entrepreneurial talent can be a significant influencing factor for successfully raising funds from crowdfunding platforms. The analysis of the case studies will reveal an appropriate pattern of the talents needed and associating factors that will help entrepreneurs become successful in obtaining funds for their business
ventures, when they elect to use crowdfunding as their financing method. Practical implications: There are four practical implications to this paper. The first, is that entrepreneurs who intend to seize the huge opportunities offered by the crowdfunding platforms should place emphasis on convincing the participants in the platforms of their talents rather than placing too much focus on perfect business plan. Secondly, the platform participants should deviate from the traditional approach of WHAT to invest in, to a new approach of WHOM/WHO to invest in. Thirdly, from the perspective of the relatively new crowdfunding industry, this paper proposes for the creation of talent-based crowdfunding platforms as opposed to the project-based ones that are currently operating. Finally, the paper encourages the academic researcher to pursue ideas and new applications in the crowdfunding industry.
The study seeks for empirical evidence supporting the presence of weak form ans semi-strong form efficiency on the Vietnamese stock market. The sample includes the daily closing value of VN-index from 9th April 2009 to 3rd of December 2014. The results from both parametric and non-parametric tests provide the evidence, which implies the weak form efficiency in the Vietnamese stock market during the recent period from 4th June 2012 to 3rd December 2014. This period is used for testing the semi-strong form efficiency on the Vietnamese stock market. The results from event study do not support the semi-strong form efficiency in the Vietnamese stock market. The empirical evidence shows a delayed reaction of nine pharmaceutical companies' stock prices toward the earnings, dividend, insider trading and regulatory announcements. The findings in this paper are crucial for investors, analysts, academicians, regulators and the development of the Vietnamese stock market.
Latin America has become a potential market in the lately years. Brazil has a potential market, being the fifth largest country in terms of population; moreover, the Brazilian economy has grown over the past years with the increasing middle class consumers. Mexico, on the other hand, with its strategic position and as a bridge for the whole American continent and having the most free trade agreements in the world is definitively an attractive investment destination. The main objective of this research is to study what type of entry modes should German companies in the high- tech industry and automotive industry use in Latin American market. As part of the research there has been a study of the internationalization theories, the entry modes and the factors that might affect the entry mode. Besides, the author has approached which characteristics do the Latin American market has and which opportunities may German Small and Medium-Sized Enterprises benefit from. Furthermore, this research incorporates some case analysis from German companies who already entered into this region, as a result there would be a analysis in order to see which patterns those companies have followed.