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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

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Author:Roman C. Hillig, Brice Sautier, Jens Schroeder, Dieter Moosmayer, Andre Hilpmann, Christian M. Stegmann, Nicolas D. Werbeck, Hans Briem, Ulf Boemer, Joerg Weiske, Volker Badock, Julia Mastouri, Kirstin Petersen, Gerhard Siemeister, Jan D. Kahmann, Dennis Wegener, Niels Böhnke, Knut Eis, Keith Graham, Lars Wortmann, Franz von Nussbaum, Benjamin Bader
DOI:https://doi.org/10.1073/pnas.1812963116
ISSN:1091-6490
Parent Title (English):Proceedings of the National Academy of Sciences of the United States of America : PNAS
Document Type:Article (peer-reviewed)
Language:English
Year of Completion:2019
Release Date:2021/05/05
Volume:116.2019
Issue:7
First Page:2551
Last Page:2560
Open Access:Frei verfügbar
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International